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This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

Additional Information:

Title: Transcriptional and Translational Regulation of Stem Cells
Author: Gary Hime,Helen Abud
Item ID: sg2oRq6dstsC
Publisher: Springer Science & Business Media
Type: BOOK
Format File: PDF & EPUB
Android/iOS: Install “Google Play Books”
Page Count: 371
Category: Medical
Published Date: 2013-05-22
Language: en
Isbn 10: 9400766211
Isbn 13: 9789400766211
Sale Info: FOR_SALE
Price: 155.99 EUR


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